Harbin Pharmaceutical Group Shiyitang Pharmaceutical Factory Using Rock Wool Panels in Its Construction

Harbin Pharmaceutical Group Shiyitang Pharmaceutical Factory Using Rock Wool Panels in Its Construction

The renovation plan for the No. 103 workshop imposed extremely high requirements on material selection, prefabrication processing, and installation techniques, as detailed below:

1. Differentiated, High-End Material Selection

Considering the different functional requirements for walls and ceilings, the plan selected two types of high-performance composite panels. All panel surfaces were required to be from well-known domestic brands like Shanghai Baosteel.

2. Extreme “Factory Prefabrication”

This was one of the most crucial measures in the plan to ensure the airtightness of the cleanroom:

Zero On-Site Cutting: All colored steel panels, including non-standard ones, must be prefabricated in the factory. On-site cutting and assembly were strictly prohibited.

Pre-Embedding and Pre-Openings: All openings required on the panels (e.g., for air ducts, conduits), along with the embedding of reinforcing furring and sealing treatment, must be completed in the factory. On-site drilling and sealing were strictly forbidden. This completely eliminated dust and debris generated by on-site construction, preventing contamination of the cleanroom.

3. Meticulous Installation Process

To ensure the final cleanroom was free of dead corners and dust accumulation, the plan specified detailed installation methods:

Connection Method: Ceiling panels were installed using a “medium word aluminum” suspension beam system. Panels were also connected using these profiles, replacing traditional point suspension, ensuring uniform panel gaps and overall airtightness.

Sealing Treatment: Panel joints were required to leave a 3mm wide and 3mm deep gap for sealant injection. Dow Corning sealant was specified, ensuring the sealant was full, dense, smooth, and bubble-free.

Standardized Accessories: Corners between walls, ceilings, and floors were uniformly finished with R=50mm aluminum alloy sprayed arc corners, eliminating 90-degree (hard-to-clean corners) and facilitating easy cleaning and disinfection.

Specific Benefits and Advantages

This high-standard construction plan brought multiple tangible benefits to the No. 103 workshop:

1. Fully Meets Stringent GMP Requirements
The plan addressed the biggest contamination risk for cleanrooms at its source: on-site construction dust. Factory prefabrication and strict installation standards ensured smooth and flat walls (surface flatness requirement ≤ 1mm), tight seams, and easy cleaning/disinfection, fully complying with GMP's core principle of “preventing contamination and cross-contamination” for facilities.

2. Creates a Top-Tier Fire Safety Barrier
Given that pharmaceutical workshops often handle flammable substances like ethanol, fire safety is paramount. The >1.0 hour fire resistance of the walls and the non-combustible Class A rock wool core effectively contain fire spread in an emergency, buying crucial time for evacuation and salvage. The MgO + rock wool composite ceiling panels provided enhanced fire protection for the technical interlayer above (typically housing pipes and cables).

3. Enables Precise Process Environment Control
The high-density rock wool core provided excellent thermal insulation (low thermal conductivity), helping maintain constant temperature and humidity in the workshop while reducing HVAC energy consumption. The ≥98% hydrophobicity rate ensured the material wouldn't absorb moisture in humid conditions, preventing microbial growth or loss of insulation performance.

4. Ensures Long-Term Stability and Reliability

Structural Stability: The plan required additional reinforcing furring inside ceiling panels spanning ≥ 2.5 meters, effectively preventing long-term sagging and deformation.

Durable Sealing: The strict requirements for sealant application ensured the long-term airtightness of the entire clean space, reducing future maintenance costs.

5. Guarantees Compliance and Traceability
The entire renovation project explicitly followed the 《Good Manufacturing Practice for Pharmaceutical Products》 (2010 Revision) standards, clearly defining requirements for all materials and processes from the tendering stage. This provided solid, verifiable documentation for subsequent drug GMP certification inspections.

This case fully demonstrates that for pharmaceutical companies, choosing rock wool panels is not merely about selecting a building material, but about adopting a systematic solution that safeguards drug safety, production compliance, and personnel well-being. Its core lies in strict material selection, factory prefabrication, and standardized installation.